Atom‐Economic Synthesis of Fully Substituted 2‐Aminopyrroles via Gold‐Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles

Abstract

A concise and flexible synthesis of fully substituted 2-aminopyrroles via gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles has been developed. Under mild reaction conditions, various 2-aminopyrrole derivatives were obtained in good to excellent yields, thus providing an efficient and atom-economic way for the construction of fully substituted 2-aminopyrroles.