Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in <i>Staphylococcus pseudintermedius</i>

Abstract

High doses of ciprofloxacin, enrofloxacin and marbofloxacin could minimize the selection of resistant mutants, whereas the possibility of selecting mutants with the conventional doses of difloxacin and orbifloxacin, and low clinical doses of all fluoroquinolones, seems high.