Activation of a Caspase-3-Independent Mode of Cell Death Associated with Lysosomal Destabilization in Cultured Human Retinal Pigment Epithelial Cells (ARPE-19) Exposed to 7β-Hydroxycholesterol

Abstract

7beta-OH induced a caspase-3-independent mode of cell death associated with lysosomal destabilization, which could play a key role in the signaling pathways leading to cell death, as shown by the ability of z-FA-fmk to counteract the cytotoxic effects of 7beta-OH.