New selective inhibitors of calcium‐activated chloride channels – <scp>T</scp>16<scp>A</scp>_inh‐<scp>A</scp>01, <scp>C</scp>a<scp>CC</scp>_inh‐<scp>A</scp>01 and <scp>MONNA</scp> – what do they inhibit?

Abstract

T16A(inh) -A01, CaCC(inh) -A01 and MONNA concentration-dependently relax rodent resistance arteries, but an equivalent vasorelaxation occurs when the transmembrane chloride gradient is abolished with an impermeant anion. These compounds therefore display poor selectivity for TMEM16A and inhibition of CaCC in vascular tissue in the concentration range that inhibits the isolated conductance.