A FreeSurfer view of the cortical transcriptome generated from the Allen Human Brain Atlas

Abstract

The Allen Human Brain Atlas provides an anatomically detailed view of gene expression in the brain. This full transcriptomic dataset contains over 200 million expression values. To facilitate use of this resource, we distilled the data into a matrix of 20,737 genes by 68 cortical regions that represent the automatically segmented FreeSurfer regions (Desikan-Killiany parcellation). In this data report, we describe the Allen-FreeSurfer mapping, sampling information and provide regional values of gene expression. The resulting cortical transcriptome facilitates interpretation of human neuroimaging findings by providing a molecular context.