A Micro-Delivery Approach for Studying Microvascular Responses to Localized Oxygen Delivery

Abstract

Oxygen saturations in capillaries positioned directly above the micro-outlets were closely associated with the controlled local O(2) oscillations. Radial diffusion from the micro-outlet is limited to ~75 μm from the center as predicted by computational modeling and as measured in vivo. These results delineate a key step in the design of a novel micro-delivery device for controlled oxygen delivery to the microvasculature to understand the fundamental mechanisms of microvascular regulation of O(2) supply.