Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells

Mei‐Mei Kau, Jiing‐Rong Wang, Shiow‐Chwen Tsai, Ching‐Han Yu, Paulus S. Wang

British Journal of Pharmacology · 2011 · 19 citations · 32 references

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Abstract

The inhibitory effects of bufalin and cinobufagin on steroidogenesis of aldosterone and cortisol were associated with inhibition of aldosterone synthase and 11β-hydroxylase, as well as the suppression of StAR protein expression and SF-1 binding to StAR promoter via the phosphorylation of ERK1/2 in H295 cells.

References

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