Enantioselective construction of spiro-1,3-indandiones with three stereocenters via organocatalytic Michael-aldol reaction of 2-arylideneindane-1,3-diones and nitro aldehydes

Abstract

Asymmetric domino reaction between 2-arylideneindane-1,3-dione and nitro aldehyde has been developed for the construction of an enantioenriched spiro-1,3-indandione framework with three stereocenters.