Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

Abstract

Increased IL-1β alters GABAergic and glutamatergic neurotransmission in hippocampus and impairs spatial learning in rats with MHE. Sildenafil reduces neuroinflammation and restores learning. Phosphodiesterase-5 inhibitors may be useful to improve cognitive function in patients with MHE.

References

Page 1

	Year	Citations
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS Jörg R. P. Geiger, Thorsten Melcher, Duk-Su Koh, Neuron Rat CnsMolecular PhysiologyMolecular NeuroscienceNeurophysiologyPhysiology	1995	1.3K
Role of interleukin‐1β in postoperative cognitive dysfunction Mario Cibelli, António Rei Fidalgo, Niccolò Terrando, Annals of Neurology	2010	737
Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis Debbie L. Shawcross, Nathan Davies, Roger Williams, Journal of Hepatology NeuropsychologySystemic Inflammatory ResponseSocial SciencesAutoimmune Liver DiseaseNeuropsychological Effects	2003	533
Behavioral Sensitization to Cocaine Is Associated with Increased AMPA Receptor Surface Expression in the Nucleus Accumbens Amy C. Boudreau, Marina E. Wolf Journal of Neuroscience Cocaine Is AssociatedNeurotransmitterNeurotransmissionNucleus AccumbensDrug Addiction	2005	486
Portacaval shunt in the rat. S H Lee, B Fisher PubMed PhysiologyElectrophysiologyRodent ManagementPortacaval Shunt	1961	384
NF- <i>k</i> appa B regulates IL-1 <i>beta</i> transcription through a consensus NF- <i>k</i> appa B binding site and a nonconsensus CRE-like site. John Cogswell, Michele M. Godlevski, G. Bruce Wisely, The Journal of Immunology	1994	370
Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy Regina Rodrigo, Omar Cauli, Ulises Gómez‐Pinedo, Gastroenterology Hepatic EncephalopathyHealth SciencesMedicineLiver PhysiologyPhysiology	2010	330
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction Niccolò Terrando, António Rei Fidalgo, Marcela P. Vizcaychipi, Critical Care	2010	220
Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice Amy M. Hein, Melissa R. Stasko, Sarah B. Matousek, Brain Behavior and Immunity Cognitive ScienceCognitive NeuroscienceMedicineMemory LossMemory	2009	218
Inflammation and hepatic encephalopathy Omar Cauli, Regina Rodrigo, Blanca Piedrafita, Hepatology	2007	204

Page 1