Concepedia

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

Vicente Hernández‐Rabaza, Ana Agustí, Andrea Cabrera‐Pastor, Santos Fustero, Óscar Delgado, Lucas Taoro‐González, Carmina Montoliú, Marta Llansola, Vicente Felipo

Journal of Neuroinflammation · 2015 · 86 citations · 34 references

DOIFull text

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Abstract

Increased IL-1β alters GABAergic and glutamatergic neurotransmission in hippocampus and impairs spatial learning in rats with MHE. Sildenafil reduces neuroinflammation and restores learning. Phosphodiesterase-5 inhibitors may be useful to improve cognitive function in patients with MHE.

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