Exogenously Administered Substance P and Neutral Endopeptidase Inhibitors Stimulate Fibroblast Proliferation, Angiogenesis and Collagen Organization during Achilles Tendon Healing

Abstract

This is the first study to demonstrate that paratendinous injections of SP after operative repair of the Achilles tendon in rats appears to provide a boost to the initial stages of healing and significantly accelerate the reparative phase of the healing process.