Infection and Immunity · 1983 · 90 citations · 10 references
Life SciencesGeneticsMolecular GeneticsGenomicsHost-pathogen InteractionsMicrobial GeneticsDisease Resistance GeneticsParasitic Disease PathogenesisResistance GenesCongenic Strain DevelopmentGenetic Markers Of ResistanceGenetic Resistance To Parasitic InfectionsHost GeneticsHost Resistance To ParasitesResistance Locus CharacterizationResistance To Parasitic InfectionSalmonella Infections
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.
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Genetic regulation of resistance to intracellular pathogens
Emil Skamene, A Forget, P A Kongshavn et al. · Nature · 1982 · 373 citations