Effects of methyl β‐cyclodextrin on EDHF responses in pig and rat arteries; association between SK_Ca channels and caveolin‐rich domains

Abstract

These data provide strong evidence that endothelial cell SK(Ca) channels are located in caveolae while the IK(Ca) channels reside in a different membrane compartment. These studies reveal cellular organisation as a further complexity in the EDHF pathway signalling cascade.