NEPHROPROTECTIVE, NEPHROCURATIVE ACTIVITY OF MIMOSA PUDICA ROOT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY

Abstract

Objective : To study nephroprotective effect of ethanolic extract of Mimosa pudica root against Gentamicin induced nephrotoxicity in rats.  Methods : After the treatment scheduled period of 21 days, the extent of nephrotoxicity with gentamicin (40 mg/kg), nephroprotection, nephrocurative activity of ethanolic extract of Mimosapudica root was estimated by serum, urine samples. In this study, we assess the serum creatinine, blood urea nitrogen (BUN), total proteins, urine volume, creatinine clearance, in vivo antioxidant parameters like MDA GSH, CAT also. Results : Plant extract of 200 mg/kg, 400 mg/kg and 600 mg/kg in serum creatinine has shown significant decrease ie., up to p<0.001 but had less significant in curative dose (600 mg/kg) ie., p<0.01. Plant extract of 400 mg/kg, 600 mg/kg and curative treatment (600 mg/kg) had shown significanct decrease in BUN and total proteins ie., up to p<0.001 but had less significance in 200 mg/kg ie., p<0.01. Plant extract 200 mg/kg, 400 mg/kg, 600 mg/kg and Curative treatment had shown increased creatinine clearence significance ie., p<0.01. All doses of ethanolic extract of Mimosa pudica root had shown significant decrease in MDA and significant increase in GSH, ie., p<0.001, Plant extract of 200 mg/kg, 400 mg/kg, 600 mg/kg has shown significant increase in catalase up to p<0.05 p<0.01 p<0.001 with respective doses. The histopathology findings supported the results. Conclusion : It is proposed that the nephroprotective, nephrocurative effect of Mimosapudica root ethanolic extract in gentamicin-induced nephrotoxicity may involve its antioxidant and oxidative radical scavenging activities.