PubMed · 2005 · 13 citations · 0 references
MedicineMolecular BiologyOncologyApoptosisCancer ImmunologyMolecular OncologyApoptosis In CancerLymphoid NeoplasmsLymphoid TissueLymphoid Tissue PathologyLymphoid TumorsOncogenic VirusesEpstein-barr Virus - Associated Lymphoid NeoplasmsEpstein-barr Virus - Associated MalignanciesGerminal Center PathologyHodgkin Lymphoma TherapyLymphoma PathogenesisLymphoma Resistance
Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitutive NF-kappaB activation and are resistant to apoptosis. This paper reviews several recent studies that for the first time implicate specific molecules in the pathogenesis of classic Hodgkin's lymphoma. Targeting these molecules could lead to the development of novel therapies for this disease.