Palladium‐Catalyzed Arylation of Unactivated γ‐Methylene C(sp³)H and δ‐CH Bonds with an Oxazoline‐Carboxylate Auxiliary

Abstract

A palladium-catalyzed arylation of unactivated γ-methylene C(sp(3) )H and remote δ-CH bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.