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FALSE-POSITIVE REACTION TO THE REGITINE TEST FOR PHEOCHROMOCYTOMA: REPORT OF A CASE

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1954

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Case Reports1 November 1954FALSE-POSITIVE REACTION TO THE REGITINE TEST FOR PHEOCHROMOCYTOMA: REPORT OF A CASERALPH D. ROSSRALPH D. ROSSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-5-1061 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRegitine (preparation C-7337) or 2-{[N-(m-hydroxyphenyl)-p-toluidino] methyl}-2-imidazoline methanesulfonate lowers the blood pressure in patients with hypertension caused by a pheochromocytoma by blocking the pressor effect of epinephrine or norepinephrine in the blood.1, 2The drug exhibits adrenolytic as well as sympatholytic effects. Regitine effectively blocks the pressor substances for longer periods than does piperoxan, and in smaller amounts.2Therefore, regitine is considered more useful and less toxic than piperoxan as a diagnostic agent to exclude the presence of pheochromocytoma as the cause of paroxysmal or sustained hypertension.2In many hospitals and clinics the regitine test has replaced the piperoxan test as...Bibliography1. RothDockertyHightower GMMBNC: Pheochromocytoma from the laboratory standpoint, S. Clin. North America 32: 1065-1077 (Aug.) 1952. CrossrefGoogle Scholar2. Council on Pharmacy and Chemistry, Phentolamine hydrochloride, J. A. M. A. 152: 1533-1535 (Aug. 15) 1953. CrossrefMedlineGoogle Scholar3. ReMineEstesDockertyPriestley WHJEMBJT: Hemiplegia resulting from pheochromocytoma, report of case, J. A. M. A. 152: 808-811 (June 27) 1953. CrossrefMedlineGoogle Scholar4. GrimsonLonginoKernodleO'Rear KSFHCEHB: Treatment of a patient with a pheochromocytoma, use of an adrenolytic drug before and during operation, J. A. M. A. 140: 1273-1274 (Aug. 20) 1949. CrossrefMedlineGoogle Scholar5. AndersonRolufsDoerner WHLSAA: The use of pharmacological tests in the diagnosis of pheochromocytoma, Am. Heart J. 43: 252-263, 1952. CrossrefMedlineGoogle Scholar6. GiffordRothKvale RWGMWF: Evaluation of new adrenolytic drug (regitine) as test for pheochromocytoma, J. A. M. A. 149: 1628-1634 (Aug. 30) 1952. CrossrefMedlineGoogle Scholar7. CalkinsDanaHoward EGWJE: Current methods of diagnosis of pheochromocytoma, J. A. M. A. 145: 880-884 (Mar. 24) 1951. CrossrefMedlineGoogle Scholar8. EmletGrimsonBellOrgain JRKSDMES: Use of piperoxan and regitine as routine tests in patients with hypertension, J. A. M. A. 146: 1383-1386 (Aug. 11) 1951. CrossrefMedlineGoogle Scholar9. LyonsLove RHVL: Clinical aspects of ganglionic and adrenergic blocking agents, in Dock, W., and Snapper, I.: Advances in internal medicine, Vol. V, 1952, The Yearbook Publishers, Chicago, pp. 303-336. Google Scholar10. Corr WP: The management of high blood pressure, M. Clin. North America 36: 1013-1024 (July) 1952. CrossrefGoogle Scholar11. BannonAllen WGEV: The effect of adrenolytic drugs on pheochromocytoma with functioning metastatic lesions: report of case, Proc. Staff Meet., Mayo Clin. 27: 459-464 (Nov. 5) 1952. MedlineGoogle Scholar12. GiffordRothKvale RWGMWF: The evaluation of use of regitine (C-7337) as a new pharmacologic test for pheochromocytoma, J. Lab. and Clin. Med. 38: 812 (Nov.) 1951. Google Scholar13. GrimsonEmletHamblen KSJREC: Diagnosis and management of tumors of the adrenal gland, Ann. Surg. 134: 451-463 (Sept.) 1951. CrossrefMedlineGoogle Scholar14. IseriHendersonDerr LTHWJW: Use of adrenolytic drug, regitine, in pheochromocytoma, Am. Heart J. 42: 129-136 (July) 1951. CrossrefGoogle Scholar15. LonginoGrimsonChittumMetcalf FHKSJRBH: Effects of a new quaternary amine and a new imidazoline derivative on the autonomic nervous system, Surgery 26: 421-434 (Sept.) 1949. MedlineGoogle Scholar16. ConsoleDunbarRay ADHSBS: Pheochromocytoma, the use of adrenergic blocking agents in the operative management, Surgery 28: 428-437 (Aug.) 1950. MedlineGoogle Scholar17. MoyerCaplovitz JHC: The clinical results of oral and parenteral administration of 2-(N′p-tolyl-N′m-hydroxyphenylaminomethyl) imidazoline hydrochloride (regitine) in the treatment of hypertension and an evaluation of the cerebral hemodynamic effects, Am. Heart J. 45: 602-610 (Apr.) 1953. CrossrefMedlineGoogle Scholar18. SpragueKvalePriestley RGWFJT: Management of certain hyperfunction lesions of the adrenal cortex and medulla, J. A. M. A. 151: 629-639 (Feb. 21) 1953. MedlineGoogle Scholar19. ClarkeHaysVan ItallieThompson CWDRTBIM: Clinical appraisal of a new adrenergic blocking agent: effect of regitine on digital blood flow in normal subjects and patients with peripheral arterial disease, Circulation 8: 715-722 (Nov.) 1953. CrossrefMedlineGoogle Scholar20. RossMitchellLarsenDillon RDREWEJR: Pheochromocytoma: report of two cases successfully treated by surgical removal, to be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 15, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnnotationsPHENTOLAMINEBibliographyPhaeochromocytoma in ChildrenPHÆOCHROMOCYTOMA: DIAGNOSIS AND MANAGEMENTPheochromocytoma: A review of the literatureParoxysmal Hypertension Due to PheochromocytomaPhaeochromocytoma: Phentolamine (Rogitine) as a Diagnostic Screening Agent in Sustained HypertensionPHEOCHROMOCYTOMA: THE VALUE OF CERTAIN TESTS USED ROUTINELY IN DIAGNOSIS*EDWARD S. ORGAIN, M.D., F.A.C.P.PHENTOLAMINE IN THE DIAGNOSIS AND MANAGEMENT OF PHÆOCHROMOCYTOMA 1 November 1954Volume 41, Issue 5Page: 1061-1066KeywordsBlood pressureDrugsEpinephrineHospitalsHypertensionNorepinephrinePheochromocytoma ePublished: 1 December 2008 Issue Published: 1 November 1954 PDF downloadLoading ...

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