Functional dysconnection in the prefrontal–amygdala circuitry in unaffected siblings of patients with bipolar I disorder

Abstract

There was a dysfunctional connection with intact GU in the dlPFC-amygdala circuit of the BDsib, which highlights the vulnerability in families with BD. Diminished top-down control from the bilateral dlPFC, which prevents adequate inhibition of limbic hyperactivity, might mediate the development of BD.