Concepedia

Publication | Open Access

Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation‐induced anaemia in rats

DOIFull Paper Access

43

Citations

22

References

2015

Year

Terrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter, Kimon C. Kanelakis, Xiaodong Wu, Wen Yan, Katherine P Merton, Freddy Schoetens, Ying Jing, Judy Skaptason,
British Journal of Pharmacology

Abstract

PHD inhibition has a beneficial effect on iron metabolism in addition to stimulating the release of EPO. Small-molecule inhibitors of PHD such as JNJ-42905343 represent a mechanism distinct from rhEPO to treat anaemia and FID.

References

YearCitations

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