PubMed · 1982 · 109 citations · 0 references
MedicineOncologyToxicologyCarcinogenesisNeoplasiaTumor PathologyCarcinogenic MechanismsChemical CarcinogenesisHepatocellular CarcinomaLiver CancerLiver DiseaseTumor ClassificationCarcinogen ClassificationClassification System DesignGenetic Predisposition To CancerHepatic TumorsLiver Tumor ClassificationLiver Tumor PromotionMechanisms Of CarcinogenicityRodent Tumor Models
Examination of three strains of inbred mice suggested that specific morphological types of hepatic tumors are the result of genetic predisposition while other types of tumors are associated with exposure to chemical carcinogens. A simple classification system is proposed. Additional studies indicated that a putative promoting agent, such as phenobarbital, increased the incidence of those tumor types usually associated with spontaneous appearance and only in strains with a genetic predisposition to spontaneous tumorigenesis. Carcinogens induce an increase in all types of tumors.