111-In-bleomycin kinetics in mice bearing transplantable tumors of lung, skin, and bone.

Abstract

Stable and chemically pure /sup 111/In-bleomycin for injection can be prepared easily from carrier-free /sup 111/InCl/sub 3/ and an aqueous solution of bleomycin by mixing the two at pH 1.5, adjusting the pH to 6.5 to 7, and autoclaving. This radiopharmaceutical shows definite tumor affinity within an hour after injection as would be predicted from its efficacy as a chemotherapeutic agent, but optimum /sup 111/In tumor-to-blood ratios in three transplantable mouse tumors are not reached for 2 days. At 48 hr postinjection, it is not known if /sup 111/In is still chelated to bleomycin. (auth)