MedicineNeuroscienceRadiologyDiagnostic ImagingDiagnostic RadiologyNeuroradiologyAge-related Physiologic ChangesBrain ImagingCognitive AgingCognitive ImpairmentMagnetic Resonance ImagingAge-related Brain ChangesBrain Atrophy In AgingMagnetic Resonance Imaging Lesion DetectionNeuroimaging MarkersStructural Magnetic Resonance Imaging MarkersWhite Matter Hyperintensity Markers
Foci of increased T2 signal intensity were found on brain MR scans in 16 (59%) of 27 healthy elderly volunteer subjects, ages 63 to 86 years old. These foci were not related to cognitive function or cerebrovascular risk factors; instead, they were highly correlated to age, being present in 11 of 11 subjects aged 75 years and over.
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Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research · 1975 · 86.9K citations
Senile Dementia of the Binswanger Type
Gustavo C. Román · JAMA · 1987 · 371 citations
Medicine, Neurology, Neuroscience +17