Studies On Pyrazolines : Preparation And Antimicrobial Activity Of 3-(3' (P-Chlorophenylsulphonamidophenyl)-5 Aryl- 1H/Acetyl Pyrazolines

Abstract

Substituted chalcones (IIa-j), prepared by the treatment of 3' (p- chlorophenylsulphonamido) acetophenone (I) with araldehyde, on condensation with hydrazine hydrate in ethanol furnished desired pyrazolines of the type (IIIa-j) and (IVa-j) respectively. The structure of the products have been assigned on the basis of elemental analyses and spectral data. The products were evaluated for their in-vitro growth inhibiting activity against several microbes. Some of the compounds showed significant antimicrobial activity.