Publication | Closed Access
P(NMe<sub>2</sub>)<sub>3</sub>-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans
70
Citations
51
References
2015
Year
Combinatorial ChemistryBiosynthesisFive-membered Cyclic MotifsEngineeringBiochemistryEnantioselective SynthesisKukhtin-ramirez AdductFacile SynthesisMedicineNovel PHeterocycle ChemistryPharmacologySynthetic ChemistryBiomolecular EngineeringDrug DiscoveryNatural Product Synthesis
A novel P(NMe2)3-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans. This reaction unveils the first practical approach to construct five-membered cyclic motifs via a Kukhtin-Ramirez adduct involved [1+4] annulation mode.
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