Superoxide Generation Links Nociceptin/Orphanin FQ (NOC/oFQ) Release to Impaired<i>N</i>-Methyl-<scp>d</scp>-Aspartate Cerebrovasodilation After Brain Injury

Abstract

These data show that NOC/oFQ, in concentrations present in cerebrospinal fluid after FPI, increased O(2)(-) production in a cyclooxygenase-dependent manner and contributes to such production after FPI. These data show that NOC/oFQ contributes to impaired NMDA-induced pial artery dilation after FPI. Therefore, these data suggest that cyclooxygenase-dependent O(2)(-) generation links NOC/oFQ release to impaired NMDA-induced cerebrovasodilation after brain injury.