The reaction of thiol compounds and chloroacetamide. 2. The reaction between chloroacetamide and cysteine peptides

Abstract

Lindley (1960) showed that the reaction between chloroacetamide and thiol compounds proceeds via the thiol anion RS-, and hence it was possible to show for cysteine and ,B-mercaptoethylamine that the two ionic species -S R -NH3+ and HS *R-NH2 occurred simultaneously in solution. The paper