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Design and biological evaluation of biphenyl-4-carboxylic acid hydrazide-hydrazone for antimicrobial activity.
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2010
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Combinatorial ChemistryPharmaceutical ScienceHydrazone DerivativesBioorganic ChemistryEscherichia ColiOrganic ChemistryAntimicrobial ChemotherapyChemistryBiphenyl-4-carboxylic Acid Hydrazide-hydrazonesPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryBiological EvaluationAntimicrobial TherapyAntimicrobial ResistanceAntimicrobial Drug DiscoveryAntibacterial AgentAntimicrobial CompoundPharmacologyBiphenyl-4-carboxylic Acid Hydrazide-hydrazoneNatural SciencesAntimicrobial ActivityMicrobiologyAntimicrobial AgentsMedicineDerivative (Chemistry)Synthetic ChemistryDrug Discovery
Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger All newly synthesized compounds exhibited promising results.