PubMed · 1978 · 73 citations · 0 references
MedicineOphthalmologyPharmacologyOcular DiseaseOcular PharmacologyOphthalmic SurgeryAqueous Humor DynamicsGlaucomaIntraocular Pressure MeasurementOcular PharmacodynamicsTopical Ophthalmic MedicationsAngle-closure Glaucoma ManagementAqueous Outflow ResistanceAqueous ProductionGlaucoma-related Outflow DysfunctionIntraocular Pressure ElevationIntraocular Pressure ManagementIntraocular Pressure ReductionOpen-angle Glaucoma Management
A 14-week course of timolol therapy in 38 eyes with open-angle glaucoma produced a statistically significant drop (6 mm Hg) in their mean intraocular pressure but had no effect on the mean coefficient of aqueous outflow. These data are compatible with those of Zimmerman et al. obtained after a single drop of treatment and suggest that timolol reduces intraocular pressure by inhibiting aqueous production.