L-Ornithine-L-Aspartate in Experimental Portal-Systemic Encephalopathy: Therapeutic Efficacy and Mechanism of Action

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts.

Bengt Hindfelt, F. Plum, Thomas E. Duffy · Journal of Clinical Investigation · 1977 · 434 citations · Full text

Life Sciences, Neurobiology, Physiology +13

Portacaval shunt in the rat.

S H Lee, B Fisher · PubMed · 1961 · 384 citations

Veterinary Medicine, Physiology, Rodent Medicine +4

Cerebral Ammonia Metabolism in Patients with Severe Liver Disease and Minimal Hepatic Encephalopathy

Alan H. Lockwood, Eddy W. H. Yap, Wai‐Hoi Wong · Journal of Cerebral Blood Flow & Metabolism · 1991 · 334 citations · Full text

Life Sciences, Neuroscience, Physiology +13

Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: Results of a placebo-controlled, double-blind study

G. Kircheis, R Nilius, Claes Held et al. · Hepatology · 1997 · 318 citations · Full text

Medicine, Internal Medicine, Pharmacology +15

Regional Differences in the Capacity for Ammonia Removal by Brain Following Portocaval Anastomosis

Roger F. Butterworth, Guylaine Girard, Jean‐François Giguère · Journal of Neurochemistry · 1988 · 117 citations

Life Sciences, Neuroscience, Physiology +15