Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. - Concepedia

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Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461.

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References

1997

Year

John C. Byrd, R B Weiss, D C Arthur, David Lawrence, Maria R. Baer, FR Davey, E S Trikha, Andrew J. Carroll, Ramana Tantravahi, Mazin Β. Qumsiyeh,

Journal of Clinical Oncology

Abstract

Patients with t(8;21) and EML have a low CR rate and overall survival. An aggressive local and systemic induction therapy should be considered for this patient subset. The effectiveness of HDAC intensification in t(8;21) patients with EML is uncertain and warrants further study.