OBSERVATIONS ON THE TREATMENT OF SUBACUTE BACTERIAL (STREPTOCOCCAL) ENDOCARDITIS SINCE 1939

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Article1 January 1945OBSERVATIONS ON THE TREATMENT OF SUBACUTE BACTERIAL (STREPTOCOCCAL) ENDOCARDITIS SINCE 1939SAUL R. KELSONSAUL R. KELSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-75 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnalysis of 250 well-authenticated cases of subacute bacterial (streptococcal) endocarditis studied during the years from 1927 to 1939 disclosed the ineffectiveness of all methods of therapy prior to the introduction of the sulfonamide drugs.1Sulfanilamide and particularly sulfapyridine appeared favorably to influence the course of the infection; in some instances, reduced fever and negative blood cultures temporarily followed the use of these drugs. Subsequent experience in the treatment of this disease has made clearer the effects of sulfanilamide and its derivatives, which are shown in the following summary. Some of the cases treated with sulfanilamide and sulfapyridine were collected from...Bibliography1. KELSONWHITE SRPD: Notes on 250 cases of subacute bacterial (streptococcal) endocarditis studied and treated between 1927 and 1939, Ann. Int. Med., 1945, xxii, 40-60. Google Scholar2. ORGAINPOSTON ESMA: Gonococcal endocarditis, with recovery after sulfapyridine, New England Jr. Med., 1939, ccxxi, 167. CrossrefGoogle Scholar3. MAJOR RH: Effect of sulfanilamide compounds on endocarditis, Am. Jr. Med. Sci., 1940, cxcix, 759. CrossrefGoogle Scholar4. ORGAINPOSTON ESMA: Bacterial endocarditis due to Streptococcus viridans; recovery following sodium sulfapyridine therapy, North Carolina Med. Jr., 1941, ii, 24. Google Scholar5. 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