Anticancer (in vitro) and Antiallergy Effects of Rice Bran Extracts

Abstract

??This study was conducted to investigate the anticancer (in vitro) and antiallergy effects of rice bran extracts. In an anticancer test using Hep3B cells and HeLa cells, water and 60% ethanol extracts of rice bran inhibited the growth of Hep3B and HeLa cell lines and morphological changes were also observed. In Hep3B cell lines, water extract of rice bran showed a higer antiproliferating effect than 60% ethanol extract. The growth-inhibitory effect against HeLa cells were 30.9% for 1,000 μg/mL, 88.8% for 3,000 μg/mL rice bran water extract. The expressions of FcεRI mRNA and c-kit in HMC-1 (human mast cell) were decreased by 60% ethanol treatment but tryptase mRNA was not changed. The extracts of rice bran inhibited histamine release from RPMC (rat peritoneal mast cell) activated by compound 48/80. Rice bran water extract showed inhibitory effect of 87% at 0.01 μg/mL concentration and 60% ethanol extract inhibited the release of histamine by 86% at 100 μg/mL concentration.