The first catalyst and solvent-free synthesis of 2-arylimidazo[2,1-b][1,3,4]thiadiazoles: a comparative assessment of greenness

Abstract

A one-pot, three-component, catalyst and solvent free synthesis of imidazo[2,1-<italic>b</italic>][1,3,4]thiadiazoles utilizing 5-aryl-1,3,4-thiadiazol-2-amines, aldehydes and isonitriles has been developed. The “greenness” was successfully evaluated within the ambits of green metrics.