Concepedia

Publication | Open Access

Sirt1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice

DOIFull Paper Access

27

Citations

19

References

2014

Year

Vina Yanti Susanti, Tsutomu Sasaki, Hiromi Yokota‐Hashimoto, Sho Matsui, Yong‐Soo Lee, Osamu Kikuchi, Mayumi Shimpuku, Hye‐Jin Kim, Masaki Kobayashi, Tadahiro Kitamura
Obesity

Abstract

Sirt1 rescues the obesity induced by insulin-resistant CN-FoxO1 in POMC neurons of male mice by decreasing FoxO1 protein through deacetylation. Sirt1 ameliorates obesity caused by a genetic model of central insulin resistance.

References

YearCitations

Page 1