17‐<scp>β</scp> Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting <scp>SIRT1</scp>/<scp>AMPK</scp>/<scp>H3</scp> acetylation

Abstract

Our results provide novel mechanisms for PMS-induced cardiovascular dysfunction involving SIRT1/AMPK/ histone H3 acetylation, which was prevented by E2. The study suggests that therapies targeting SIRT1/AMPK/epigenetic modifications may be beneficial in reducing the risk of cardiovascular disorders.