Zn(<scp>ii</scp>) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction - Concepedia

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Zn(<scp>ii</scp>) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction

DOI Full Paper Access

35

Citations

80

References

2015

Year

Nenad R. Filipović, Snežana Bjelogrlić, Аleksandar Marinković, Tatjana Ž. Verbić, Ilija Cvijetić, Milan Senćanski, Marko V. Rodić, Miroslava Vujčić, Dušan Sladić, Zlatko Striković,

ApoptosisImmunologyMolecular BiologyCell Death2-Quinolinecarboxaldehyde SelenosemicarbazoneChemical BiologyCellular PhysiologyTumor BiologyInorganic CompoundSignaling PathwayPancreatic CancerNew ZnCell SignalingInorganic ChemistryConcentration-dependent Apoptotic ResponseBiochemistryCell BiologyInorganic SynthesisInteraction StudiesExtensive ActivationMolecular DockingSignal TransductionNatural SciencesCoordination ComplexMolecular ComplexMedicine

Abstract

A new Zn(<sc>ii</sc>)-based complex shows a concentration-dependent apoptotic response in highly resistant pancreatic adenocarcinoma cells with extensive activation of caspase-8 and -9.

References

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