Plasmacytoid Dendritic Cell-Derived IFN-α Promotes Murine Liver Ischemia/Reperfusion Injury by Induction of Hepatocyte IRF-1

Abstract

these data support the hypothesis that IFN-α derived from liver pDC plays a key role in the pathogenesis of liver I/R injury by enhancing apoptosis as a consequence of induction of hepatocyte IRF-1 expression.