Journal of Clinical Oncology · 1984 · 43 citations · 0 references
MedicinePharmacologyPharmacotherapyChemotherapyClinical PharmacologyOncology PharmacotherapyAntiemetic PharmacologyAntiemetic TherapyMedication Side Effect ManagementNausea ControlVomiting ControlVomiting ManagementAntiemetic Efficacy EvaluationAntiemetic TolerabilityChemotherapy-induced Vomiting PreventionComparative Effectiveness Of AntiemeticsDexamethasone For AntiemesisMetoclopramide TherapyMetoclopramide UsePatient Preference Measurement
In a randomized, crossover design the antiemetic activity of one of the most active single agents, metoclopramide was compared with a combination of dexamethasone and lorazepam. Both regimens were effective, but dexamethasone-lorazepam was significantly better than metoclopramide in preventing (26% versus 13%) or limiting (44% versus 23%) vomiting. Although side effects were more frequent with lorazepam-dexamethasone, the patients generally judged them desirable and overall patient preference was strong (70% versus 12%) for the lorazepam-dexamethasone combination. Patients required supervision and assistance due to lorazepam-induced drowsiness.