Chemistry - A European Journal · 2015 · 29 citations · 37 references
Asymmetric CatalysisChemical EngineeringCross-coupling ReactionEngineeringOrganic ChemistryPalladium/copper‐cocatalyzed Oxidative AmidobrominationsCatalysisOxidative Enamide BrominationChemistryOrganometallic CatalysisDual Nh/ch CouplingSynthetic ChemistryDomino Process
In the presence of LiBr, a palladium/copper combination catalyzes dehydrogenative amidobrominations of acrylates with NH-sulfoximines, leading to N-vinylated products by dual NH/CH coupling, followed by oxidative enamide bromination. Mechanistically, the domino process is proposed to involve palladium(II) species as key intermediates. First synthetic applications of the products have been demonstrated.
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