Direct Access to Fully Substituted 3‐Formyl‐4‐iodofurans through Iodocyclization of α‐Alkynyl β‐Alkoxy Enones

Abstract

Abstract A facile access to 3‐formyl‐4‐iodofurans is presented. This protocol consists of a Sonogashira cross‐coupling of an α‐iodo β‐alkoxy enone with a terminal alkyne and the subsequent iodonium‐promoted heteroannulation–dealkoxylation of the resulting α‐alkynyl β‐alkoxy enone by treatment with N ‐iodosuccinimide in aqueous medium.