A Facile Synthesis of Mollugin

Abstract

Mollugin (1) is one of the major 2H-naphtho[1,2-b]pyran component isolated from Rubiaceae species such as Putoria calabrica and Rubia cordifolia L. (Rubiaceae), a herbal medicine used for the treatment of arthritis, dysmenorrhea, hematorrhea, and hemostasis, as a tonic, and for wound healing in China and used for menstrual pain, rheumatism, and urinary disorders in India. Antitumor activity, antimutagenic activity, antiviral activity against hepatitis B virus, and strong inhibitory activity on arachidonic acid and collagen-induced platelet aggregation of mollugin have been reported. In addition, mollugin inhibited cell adhesion between angioendothelial cells and lymphocytes thus having potentials for cosmetic additives with hair growth stimulant activity and anti-aging activity.