Indian Journal of Pharmacology · 1980 · 172 citations · 0 references
MedicineEndocrinologyPharmacologyBiochemical PharmacologyCellular PharmacologyRegenerative MedicineDiabetes ManagementDiabetes MellitusDiabetes PharmacotherapyInsulin ResistanceMedicinal PlantsPancreatic EndocrinologyAcute Drug ToxicityAntidiabetic ActivityAntidiabetic Drug TherapyBeta Cell RegenerationBeta-cell DysfunctionFlavonoid GlycosidesPancreatic Beta-cell FunctionPancreatic Islet Cells
. A flavonoid fraction (XE) extracted from the bark of pterocarpus marsupium Roxb. (Leguminoceae) was studied for the hypoglycaemic activity normal and alloxanised albino rats. The drug XE did not show a consistent effect on normal blood sugar levels but it effectively reversed the alloxan-induced changes in the blood sugar level and the beta-cell population in the pancreas. It also showed a protective effect when it was given prior to alloxan administration. The novel action of drug on the pancreatic beta-cells and absence of acute toxicity may offer a new hope to the diabetics in future.