APOLIPOPROTEIN E GENE POLYMORPHISM, ALCOHOL USE, AND THEIR INTERACTIONS IN COMBAT-RELATED POSTTRAUMATIC STRESS DISORDER

Abstract

These results suggest that the APOE ε2 allele operates as a susceptibility gene for combat-related PTSD, with the relationship between alcohol use and PTSD differing according to the ε2-allele status. Future studies should determine the role of the APOE in adaptation to extreme stress, the development of PTSD, and comorbid alcohol-related disorders.