Up-Regulation of Micro-RNA765 in Human Failing Hearts is Associated with Post-Transcriptional Regulation of Protein Phosphatase Inhibitor-1 and Depressed Contractility

Abstract

miR-765 levels are increased in human failing hearts. Such increases may contribute to depressed cardiac function through reduced inhibitor-1 expression and enhanced PP-1 activity, associated with reduced SR Ca(2+) load.