Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and <scp>N</scp>‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats

Abstract

Both hydrogen-rich saline and N-acetylcysteine alleviate portal hypertension, the severity of portosystemic collaterals, mesenteric angiogenesis, hepatic endothelial dysfunction and intrahepatic resistance in cirrhotic rats. N-Acetylcysteine and the new antioxidant, hydrogen-rich saline are potential treatments for the complications of cirrhosis.