Technetium-99m-white blood cell-specific imaging agent developed from platelet factor 4 to detect infection.

Abstract

Technetium-99m-P483H associates predominantly with WBCs in vitro and identified focal infections in vivo within 4 hr versus conventional imaging agents. Additionally, the agent showed rapid blood clearance and exclusive renal excretion, which provides a clear abdominal field for imaging abdominal infections.