Citrullination of Epithelial Neutrophil–Activating Peptide 78/CXCL5 Results in Conversion From a Non–Monocyte‐Recruiting Chemokine to a Monocyte‐Recruiting Chemokine

Abstract

Citrullinated ENA-78/CXCL5 is highly correlated with RA disease activity and, unlike noncitrullinated ENA-78/CXCL5, recruits monocytes. These results indicate that citrullinated ENA-78/CXCL5 may exert previously unrecognized inflammatory properties in RA by recruiting monocytes to inflamed joint tissue.