Concepedia

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Autophagy inhibition can overcome radioresistance in breast cancer cells through suppression of TAK1 activation.

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Citations

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References

2014

Year

Myung Woul Han, Jong Cheol Lee, Junyoung Choi, Gui Chul Kim, Hyo Won Chang, Hae Yun Nam, Seong Who Kim, Sang Yoon Kim
PubMed

Abstract

Inhibition of autophagy enhanced radiosensitivity through suppression of radiation-induced TAK1 activation, suggesting that the modulation of TAK1-induced autophagy may be a good therapeutic strategy to treat radioresistant breast cancer.