OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 1985 · 21 citations · 0 references
PharmacyToxicologyVeterinary ToxicologyHypersensitivityNeurotoxicologyOcular PharmacologyDermal ToxicityOcular IrritationOcular ToxicologyRodent ToxicologyUveal DiseaseChronic UveitisCorneal IrritationEye IrritationGuinea Pig ModelsOcular Irritant TestingOcular Toxicity AssessmentOcular Toxicity EvaluationOcular Toxicity Testing
The acute oral LD/sub 50/ values for NTO for mice and rats are greater than 5 g/kg. According to classical guidelines, the test material would be considered only slightly toxic or practically non-toxic in both species. Skin application studies in the rabbit with NTO demonstrated that it was mildly irritating cutaneously. With the scoring scheme, the rabbit eye test was considered negative; however, transient conjunctival and corneal irritation did result from the NTO application in several animals and one developed a chronic anterior uveitis. The material did not induce sensitization in the intradermal guinea pig assay. 6 refs., 1 tab.