The Journal of Dermatologic Surgery and Oncology · 1994 · 228 citations · 21 references
MedicineDermatologyOphthalmologyBiophotonicsDermatologic SurgeryDermatopathologyBiomedical Laser ApplicationsHyperpigmentation TreatmentLaser SurgeryMelasma ManagementSkin RejuvenationTattoo RemovalCafe-au-lait MaculesDermatologic Laser TreatmentLaser Therapy For MelasmaLasersNevus SpilusPigmented Lesion TreatmentQ-switched Laser Tattoo RemovalSide Effect Profile
BACKGROUND: The Q-switched ruby laser (QSRL) (694 nm) has been used successfully in the removal of tattoos and a variety of cutaneous pigmented lesions. The frequency-doubled Q-switched neodymium:yttrium-aluminum-garnet laser (QSNd:YAG) (1064 and 532 nm) has also been shown to be effective in the treatment of tattoos, however, little has been published regarding the QSNd:YAG laser in the removal of cutaneous pigmented lesions. OBJECTIVE: The purpose of this study is to compare the efficacy and side effect profile of the QSRL and the frequency-doubled QSNd:YAG lasers in the removal of cutaneous pigmented lesions, including lentigines, café-au-lait macules, nevus of Ota, nevus spilus, Becker's nevus, postinflammatory hyperpigmentation, and melasma. METHODS: Twenty patients with pigmented lesions were treated with the QSRL and the frequency-doubled QSNd:YAG lasers. Clinical lightening of the lesion was assessed 1 month after a single treatment. Side effects and patient satisfaction were also evaluated. RESULTS: A minimum of 30% lightening was achieved in all patients after only one treatment with either the QSRL or the frequency-doubled QSNd:YAG laser. The QSRL seems to provide a slightly better treatment response than the QSNd:YAG laser. Neither laser caused scarring or textural change of the skin. Most patients found the QSRL to be more painful during treatment, but the QSNd:YAG laser caused more postoperative discomfort. CONCLUSION: Both the QSRL and the frequency-doubled QSND:YAG laser are safe and effective methods of treatment of epidermal and dermal pigmented lesions.
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Ludwig A. Sternberger, Paul H. Hardy, John J. Cuculis et al. · Journal of Histochemistry & Cytochemistry · 1970 · 5.1K citations · Full text