Comparison of the effects of systemic sildenafil, tadalafil, and vardenafil treatments on skin flap survival in rats

Abstract

The ratio of flap necrosis area tended to be lower in the groups receiving oral PDE5 inhibitors than in the control group, although not statistically significant. The role of PDE5 inhibitors needs to be evaluated in larger studies before a conclusion can be made regarding their effects on flap viability.